Chromophore for UV-induced Immunosuppression: DNA
نویسندگان
چکیده
منابع مشابه
Mechanisms of UV-induced immunosuppression.
Ultraviolet radiation (UV), in particular the UVB range, suppresses the immune system in several ways. UVB inhibits antigen presentation, induces the release of immunosuppressive cytokines and causes apoptosis of leukocytes. UVB, however, does not cause general immunosuppression but rather inhibits immune reactions in an antigen-specific fashion. Application of contact allergens onto UV-exposed...
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UV light can be highly beneficial in the treatment of skin disorders such as psoriasis. It is thought to cause immunosuppression by depleting or altering the function of epidermal Langerhans cells (LC). Our previous studies identified a novel langerin(+) dendritic cell in the dermis, distinct from LC in phenotype, circulation, and function. In this study, we determined the role of LC and dermal...
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The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosuppression. Thus, we initiated studies into immune restoration by IL-12 to discern whether its eff...
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The microstructural requirements for optimal interaction of neocarzinostatin chromophore (NCS-C) with DNA have been investigated using a series of hexadeoxyribonucleotides with modified bases such as O6-methyl G (MeG), I, 5-methyl C (MeC), U, or 5-Bromo U (BrU) at specific sites in its preferred trinucleotide 5'GNaNb3':5'Na,Nb,C3' (Na = A, C, or T). Results show that MeG:C and G:MeC in place of...
متن کاملGreen tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes.
UV radiation-induced immunosuppression has been implicated in the development of skin cancers. Green tea polyphenols (GTP) in drinking water prevent photocarcinogenesis in the skin of mice. We studied whether GTPs in drinking water (0.1-0.5%, w/v) prevent UV-induced immunosuppression and (if so) potential mechanisms of this effect in mice. GTPs (0.2% and 0.5%, w/v) reduced UV-induced suppressio...
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ژورنال
عنوان ژورنال: Photochemistry and Photobiology
سال: 1996
ISSN: 0031-8655,1751-1097
DOI: 10.1111/j.1751-1097.1996.tb03050.x